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地塞米松对大鼠脑出血后周围脑组织MMP-9表达的影响
引用本文:王善军,王道奎,王玉亭,闫瑞云. 地塞米松对大鼠脑出血后周围脑组织MMP-9表达的影响[J]. 淮海医药, 2011, 29(4): 285-287
作者姓名:王善军  王道奎  王玉亭  闫瑞云
作者单位:1. 潍坊医学院,外科学教研室,山东,潍坊,261042
2. 山东省潍坊市脑科医院,261041
3. 山东省昌乐县人民医院,262400
摘    要:目的 探讨地塞米松(DEX)对大鼠实验性脑出血后基质金属蛋白酶-9(MMP-9)表达的影响.方法 63只健康雄性Wistar大鼠采用自体血注入法建立右侧基底节区脑出血模型,随机分为A、B、C 3组,A组为DEX干预组;B组为脑出血模型组;C组为假手术对照组,造模成功后每天给予A组DEX(1 ml/kg)腹腔注射,B、C...

关 键 词:脑出血  地塞米松  基质金属蛋白酶-9

Interference of DEX application to the expression of MMP-9 in the area around hematoma in rats : An experimental study
Affiliation:WANG Shan-jun,WANG Dao-kui,WANG Yu-ting,et al.(Department of Surgery,Weifang Medical College,Shandong 261053,China)
Abstract:Objective To study the relationship between the expression of matrix metalloproteinase-9(MMP-9) around the hematoma and the application of dexamethasone(DEX) after intra-cerebral hemorrhage(ICH).Methods Sixty-three healthy male Wistar rats were randomly divided into three groups:ICH with DEX treatment group(group A),ICH group(group B) and sham operation group(group C).The model of ICH in right ganglia was established by autologous blood injection.After modeling,the rats of group A were given a daily intra-peritoneal injection of DEX(1ml/kg).Groups of B and C were given equivalent normal saline instead.After intervention,the rats were decapitated respectively,at time points of 6h,12h,24h,3d,7d and 14d.The expression of MMP-9 was measured by immunohistochemistry technique.Results The expression of MMP-9 in group A was lower than that in group B(P0.05).The expression of MMP-9 in groups A and B was higher than that in group C(P0.05).Conclusion The application of DEX can decrease the expression of MMP-9 in the area around hematoma.The change in the expression of MMP-9 may be used as a channel to alleviate cerebral edema.
Keywords:Cerebral hemorrhage  Dexamethasone  Matrix metalloproteinase-9
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