| 纳米细菌致兔胆囊结石的研究 |
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| 引用本文： | 刘亚楠,张国彬,马立人.纳米细菌致兔胆囊结石的研究[J].华北煤炭医学院学报,2011,13(4). |
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| 作者姓名： | 刘亚楠 张国彬 马立人 |
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| 作者单位： | 河北联合大学基础医学院免疫学教研室,河北唐山,063000 |
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| 摘 要： | ①目的 通过对胆汁培养的纳米细菌(Nanobacteria Nb)感染日本大耳白兔致胆结石形成,探讨纳米细菌感染与胆石症发生的相关性.②方法 用从胆汁中培养出的纳米细菌感染日本大耳白兔,3周后处死日本大耳白兔,记录成石情况.③结果 胆石症患者胆汁纳米细菌感染性实验中纳米细菌感染组胆结石发生率81.25%与DMEM对照组6.25%和羟基磷灰石(Hap)对照组18.75%比较,差异有统计学意义(P＜0.05).日本大耳白兔胆汁纳米细菌感染性实验中Nb感染组胆结石发生率56.25%与含各种氨基酸和葡萄糖的培养基(DMEM)对照组6.25%和灭活纳米细菌对照组12.50%比较,差异有统计学意义P＜0.05.④结论 实验动物感染纳米细菌后能在短期内产生胆囊结石;由被感染的实验日本大耳白兔胆汁培养出的纳米细菌能再次感染日本大耳白兔并致胆结石形成.
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| 关 键 词： | 纳米细菌 感染 胆结石 |
Research of nanobacteria leading to rabbit gallstone produce |
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| LIU Yanan,ZHANG Guobin,MA Liren.Research of nanobacteria leading to rabbit gallstone produce[J].Journal of North China Coal Medical College,2011,13(4). |
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| Authors: | LIU Yanan ZHANG Guobin MA Liren |
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| Institution: | LIU Yanan,ZHANG Guobin,MA Liren(Department of Immunology,College of Elementary Medicine,Hebei United University,Tangshan 063000,China) |
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| Abstract: | Objective In order to testify the correlation between nanobacteria infection and cholecystolithiasis,we infected rabbits with nanobactria cultured from bile to lead to rabbit gallstone produce.Methods The rabbits were infected by nanobactria cultured from bile.After 3 weeks,we euthanized the rabbits to count the gallstones.Results In the infective experiment of nanobacteria cultured from cholelithiasis patients,the gallstone incidence of Nb infected group(13/16)was significantly greater than that in DMEM co... |
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| Keywords: | Nanobacteria Infection Gallstone |
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