| 心房颤动患者血小板活化与左心房血栓形成关系的研究 |
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| 引用本文： | 王志荣,张超群,程仁力,吴建东,徐晤,杨煜,夏勇,李东野.心房颤动患者血小板活化与左心房血栓形成关系的研究[J].中国循环杂志,2008,23(4). |
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| 作者姓名： | 王志荣 张超群 程仁力 吴建东 徐晤 杨煜 夏勇 李东野 |
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| 作者单位： | 徐州医学院附属医院,心内科,江苏省徐州市,221000 |
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| 摘 要： | 目的:探讨持续性心房颤动(房颤)患者血小板活化与左心房血栓形成的关系.方法:选择持续性房颤患者(房颤组)84例,窦性心律(窦律组)和正常对照组各20例,其中房颤组39例患者通过经食道超声心动图检查又分为血栓阳性者(22例)和血栓阴性者(17例).所有对象均用流式细胞仪检测全血中血小板膜活化糖蛋白(GP)Ⅱb/Ⅲa水平.结果:左心房内径和血中GPⅡb/Ⅲa水平比较:与正常对照组、窦律组比较,房颤组的左心房内径、GPⅡb/Ⅲa活化阳性血小板的百分率明显增高,差异有统计学意义(P＜0.05).进一步分析结果发现,与正常对照组、窦律组比较,血栓阴性者和血栓阳性者的左心房内径、GPⅡb/Ⅲa活化阳性血小板的百分率明显增高,差异有统计学意义(P＜0.05);且血栓阳性者的左心房内径、GPⅡb/Ⅲa活化阳性血小板的百分率明显高于血栓阴性者,差异有统计学意义(P＜0.05).多元线性回归分析:发现GPⅡb/Ⅲa活化阳性血小板的百分率(t=4.07,P=0.000)是房颤患者左心房血栓形成的独立危险因素,而左心房内径无明确的预测价值(t=1.78,P=0.084).相关性分析:使用直线相关分析方法,分析房颤患者血中GPⅡb/Ⅲa水平同左心房内径的关系,发现GPⅡb/Ⅲa水平同左心房内径两者具有相关性(r=0.57,R2=0.33,P＜0.01).结论:持续性房颤患者存在血小板活化程度增加,且同左心房血栓形成有密切关系.
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| 关 键 词： | 心房颤动 血栓 血小板膜活化糖蛋白Ⅱb/Ⅲa |
The Relationship Between Activated Platelet and Left Atrial Thrombosis in Patients With Atrial Fibrillation |
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| WANG Zhi-rong ZHANG Chao-qun CHENG Ren-li,et al..The Relationship Between Activated Platelet and Left Atrial Thrombosis in Patients With Atrial Fibrillation[J].Chinese Circulation Journal,2008,23(4). |
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| Authors: | WANG Zhi-rong ZHANG Chao-qun CHENG Ren-li |
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| Institution: | WANG Zhi-rong ZHANG Chao-qun CHENG Ren-li,et al.Department of Cardiology,Affiliated Hospital of Xuzhou Medical College,Xuzhou(221000),Jiangsu,China |
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| Abstract: | Objective:To investigate the relationship between platelet activation and left atrial thrombosis in patients with atrial fibrilla- tion(AF). Methods:Among 84 patients with persistent AF,39 patients were divided into thrombosis positive group(22 cases)and thrombosis negative group(17 cases)according to the result of transthoracic and transesophageal echocardiography.As the con- trol,sinus rhythm group(20 patients with various heart disease)and normal group(20 healthy subjects)were included in this study.The ... |
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