| HIFU辐照兔腹主动脉粥样硬化血管后血流动力学的变化 |
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| 引用本文： | 蒋明东,白晋,王智彪,于廷和,杜永洪,龚晓波,王燕芹,李崇雁,卢岷. HIFU辐照兔腹主动脉粥样硬化血管后血流动力学的变化[J]. 临床超声医学杂志, 2004, 6(4): 196-198 |
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| 作者姓名： | 蒋明东 白晋 王智彪 于廷和 杜永洪 龚晓波 王燕芹 李崇雁 卢岷 |
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| 作者单位： | 400016,重庆医科大学生物医学工程系,医学超声工程研究所;400010,重庆医科大学附属第二医院超声科 |
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| 基金项目： | 国家自然科学基金资助 (30 1 71 0 60 ) |
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| 摘 要： | 目的 观察HIFU辐照兔腹主动脉粥样硬化 (atherosclerosis ,AS)血管后血流动力学的变化 ,确定HIFU的安全性。方法 以CDFI和DSA检测HIFU辐照兔AS及对照组腹主动脉后不同时间血管血流的变化 ,测定血流动力学指标。结果 48只兔 (AS组 :n1=2 4,对照组 :n2 =2 4) ,HIFU辐照后CDFI示动脉峰值血流速度、平均血流速度、阻力指数、搏动指数、血流量及血流量下降百分比均下降 (P <0 .0 5 )。DSA示动脉血流阻滞、充盈延迟 ,无血管栓塞和破裂 ;5d及 10d观察动脉血流呈向正常恢复趋势 ,对照组恢复更好。结论 HIFU辐照兔腹主动脉AS血管将导致可逆的血流动力学改变 ,HIFU辐照兔腹主动脉粥样硬化血管具有相对安全性
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| 关 键 词： | 高强度聚焦超声 粥样硬化腹主动脉 兔 血流动力学 |
| 修稿时间： | 2004-02-13 |
Hemodynamic Changes of the Atheromatous Abdominal Aorta of Rabbits Treated with High Intensity Focused Ultrasound |
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| Jiang Mingdong,Bai Jin,Wang Zhibiao,et al.. Hemodynamic Changes of the Atheromatous Abdominal Aorta of Rabbits Treated with High Intensity Focused Ultrasound[J]. Journal of Ultrasound in Clinical Medicine, 2004, 6(4): 196-198 |
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| Authors: | Jiang Mingdong Bai Jin Wang Zhibiao et al. |
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| Affiliation: | Jiang Mingdong,Bai Jin,Wang Zhibiao,et al. Dept of Biomedical Engineering,Chongqing University of Medical Sciences,Chongqing Institute of Ultrasound Engineering in Medicine,Chongqing 400016,China |
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| Abstract: | Objective To evaluate the hemodynamic changes of the atheromatous abdominal aorta of rabbits treated by high intensity focused ultrasound (HIFU).Methods Color Doppler flow imaging (CDFI) and DSA were used to evaluate the pathologcial and hemodynamic changes of abdominal aorta immediately, 5th and 10th day after HIFU exposure.Results Maximal velocity (Vmax), minimal velocity (Vmin), pulse index (PI) and resistance index (RI) of the abdominal aorta in both groups were significantly changed after exposure to HIFU (P<0.05). Conclusion HIFU ablation resulted in reversible hemodynamics changes of atheromatous abdominal aorta. |
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| Keywords: | High intensity focused ultrasound Atheromatous abdominal aorta Rabbits Hemodynamics |
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