Schistosoma mansoni: Analysis of monoclonal antibodies reactive with gut-associated antigens |
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| Authors: | Govert J van Dam Dieuwke Kornelis René J M Van Zeyl J Peter Rotmans André M Deelder |
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| Institution: | (1) Laboratory for Parasitology, University of Leiden, P.O. Box 9605, 2300 RC Leiden, The Netherlands |
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| Abstract: | The analysis of a series of monoclonal antibodies (mAbs) developed in our laboratory against gutassociated antigens ofSchistosoma mansoni is described. It was found that mAbs that recognized epitopes of antigens in the gut and on the eggshell were mainly of the IgM isotype; these epitopes are likely to be carbohydrate in composition. Of a number of mAbs that were reactive with antigens important to the human humoral immune response, 75% appeared to be reactive with the circulating cathodic antigen. |
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