铅对小鼠仔代神经行为影响的实验研究

本文研究了通过胎盘和乳汁暴露铅对小鼠仔代神经行为的影响。结果提示：铅可经母体传递给仔代，并可进入仔代的中枢神经系统；在生长发育受阻前，低浓度铅（血铅值１．２５μｍｏｌ／Ｌ）即可引起仔鼠视觉识别功能下降，情感行为变化；更高浓度的铅（血铅值２．８μｍｏｌ／Ｌ）则进一步导致仔鼠神经反射发育迟缓，但在本实验铅浓度下，未发现大脑神经元形态改变。

Effect of lead on the neurobehavior of newborn mice

The effects of pre-and postnatal exposure to lead acetate on the neurobehavior development of newborn mice were studied. Oral administration of lead acetate (0. 05%, 0. 1%) was given to pregnant mice daily until weaned. The results of behavioral tests indicate that some behavioral development of newborn mice, especialy the visual discrimination function was retarded. It is suggested that the mother's lead could be transferred to the filial generation during pregnancy and lactation.