进展型脑梗死血脂、血流变、血凝检测的临床意义

目的研究进展型脑梗死患者血脂、血流变、血凝指标的变化,探讨进展型脑梗死的发病机制,为其临床早期诊断和治疗提供依据。方法对比检测了72例进展型脑梗死患者与72例完全型脑梗死患者血浆凝血酶原时间、凝血酶时间、部分凝血活酶时间、纤维蛋白原水平和血脂、血液流变学的各项指标。结果与完全型脑梗死患者比较,进展型脑梗死患者的血浆凝血酶原时间、凝血酶时间、部分凝血活酶时间显著缩短,而纤维蛋白原水平显著升高(P<0.01、0.05);血总胆固醇、甘油三酯、低密度脂蛋白水平明显增高(P<0.01、0.05);全血粘度、全血还原黏度、红细胞聚集指数和红细胞变形指数均较完全型组明显升高(P<0.010、.05)。结论进展型脑梗死患者存在着明显的高凝血状态、血流变的异常和高脂血症。

Study on the of Changes in Serum lipids Coagulation and Hemorheology in Patients with Progressive Cerebral Infarction

Objective To explore the pathogenesis and laboratory test of progressive cerebral infarction.Methods Prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(Fib),the level of blood lipids and the indicators of hemorheology were measured in 72 patients with progressive cerebral infarction and 72 patients with complete cerebral infarction.Results Compared with complete cerebral infarction patients,PT,TT and APTT in patients with progressive cerebral infarction were significantly shorter.The concentration of Fib and the levels of TC,TG and LDL were significantly higher in patients with progressive cerebral in farction(P<0.05-0.01).The whole blood viscosity(high shear,middle shear,low shear),the whole blood restore viscosity and RBC aggregation,RBC deformability were significantly higher in patients with progressive cerebral infarction than those in patents with complete cerebral infarction(P<0.05-0.01).Conclusions The function of coagulation and the contents of blood lipids in the patients with progressive cerebral infarction are significantly stronger or higher than those in patients with complete cerebral infarction and significan abnormal alteration of hemorheology exists in patients with progressive cerebral infarction.