系统性红斑狼疮患者自身抗检测的临床意义

目的 探讨多项自身抗体检测在系统性红斑狼疮（SLE）诊断中的意义.方法 采用免疫荧光技术测定抗核抗体（ANA）和抗双链DNA抗体（抗ds-DNA）,采用免疫印迹技术测定抗可提取性核抗原抗体（抗-ENA）.结果 83例SLE患者ANA阳性率为93.6%,抗-dsDNA阳性率为67.9%,抗-ENA总阳性率为53.1%,抗-dsDNA和抗-ENA联合检测阳性率为82.3%.结论 自身抗体检测可提高SLE患者的诊断率.

The clinical significance of autoantibody detection in systemic lupus erythematosus patients

Objective To explore significance of many autoantibodies detection in systemic lupus erythematosus （SLE） diagnosis. Methotis Anti-nuclear antibody （ANA） and anti- double- stranded DNA antibodies （anti- ds-DNA） was measured by Immunofluorescence, anti - extractable nuclear antigen antibodies （anti - ENA） was measured by Western blot. Results 83 cases of SLE patients with ANA positive rate was 93.6%, anti - dsDNA positive rate was 67.9%, anti - ENA positive rate was 53.1%, anti - dsDNA and anti - ENA combined detection positive rate was 82.3%. Conclusions Autoantibodies detection can improve the diagnostic rate in patients with SLE.