| 三维适形放疗加甘氨双唑钠增敏治疗局限晚期非小细胞肺癌的疗效分析 |
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| 引用本文： | 王俊超,刘慧忠,郝澄澄,田光亮,王湘连.三维适形放疗加甘氨双唑钠增敏治疗局限晚期非小细胞肺癌的疗效分析[J].山东大学学报(医学版),2009,47(1):91-94. |
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| 作者姓名： | 王俊超 刘慧忠 郝澄澄 田光亮 王湘连 |
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| 作者单位： | 王俊超,刘慧忠,郝澄澄,田光亮,WANG Jun-chao,LIU Hui-zhong,HAO Cheng-cheng,TIAN Guang-liang(山东大学齐鲁医院肿瘤防治研究中心,济南,250012);王湘连,WANG Xiang-lian(复旦大学附属华东医院放疗科,上海,200040)
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| 摘 要： | 目的研究甘氨双唑钠加三维适形放疗（3DCRT）对局限晚期非小细胞肺癌（NSCLC）的疗效和不良反应。方法随机将77例局限晚期非小细胞肺癌患者分为三维适形放疗加甘氨双唑钠（CMNa）组(A组)和单纯三维适形放疗组(B组)，评价近期疗效和毒副作用。结果A组的有效率（CR+PR）明显高于B组，分别为76.9%、52.6%(χ2=4.99，P=0.026）；应用甘氨双唑钠后肿瘤病灶完全缓解时的放疗增敏比（SER）为1.21，达部分缓解时为1.40。2组的毒副反应差异无统计学意义。结论甘氨双唑钠对局限晚期非小细胞肺癌的三维适形放疗有敏感作用,可以提高近期疗效。
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| 关 键 词： | 癌 非小细胞肺 放射疗法 适形 硝基咪唑类 |
Radio-sensitization effect of three-dimensional conformal radiotherapy combined with metronidazole amino acidum natrium for local advanced non-small cell lung cancer |
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| WANG Jun-chao,LIU Hui-zhong,HAO Cheng-cheng,TIAN Guangliang,WANG Xiang-lian.Radio-sensitization effect of three-dimensional conformal radiotherapy combined with metronidazole amino acidum natrium for local advanced non-small cell lung cancer[J].Journal of Shandong University:Health Sciences,2009,47(1):91-94. |
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| Authors: | WANG Jun-chao LIU Hui-zhong HAO Cheng-cheng TIAN Guangliang WANG Xiang-lian |
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| Institution: | 1.Cancer Center;Qilu Hospital of Shandong University;Jinan 250012;China;2.Department of Radiotherapy;Huadong Hospital;Fudan University;Shanghai 200040;China |
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| Abstract: | Objective To evaluate the effect and complication of metronidazole amino acidum natrium combined with three-dimensional conformal radiotherapy (3-DCRT) for local advanced non-small cell lung cancer(NSCLC).Methods Seventy-seven patients with local advanced non-small cell lung cancer(NSCLC) were randomly divided into group A(CMNa+3-DCRT)and group B(3-DCRT alone).The short-term response and toxicity of the two groups were observed.Result The response rate(CR+PR) in group A was significantly higher than that in... |
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| Keywords: | Cancer non-small cell lung Radiotherapy conformal Nitroimidazoles |
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