晚期非小细胞肺癌的中西医结合治疗

目的:为了探讨中西医结合对晚期非小细胞肺癌的治疗作用。方法:自1992年5月至1996年8月在该科住院的106例晚期非细胞肺癌随机分为两组:A组52例中药加化疗,B组54例单用化疗,两组化疗方案大致相同。A组所用中药遵循辨证论治分为肺脾气虚、肺热痰湿、肺胃阴虚和气滞血淤型。结果:A组和B组根据WHO标准治疗有效率分别为42.6％和40.7％(P>0.05);1年存活率分别为69.2％和61.1％(P>0.05);2年存活率分别为44.6％和16.6％(P<0.01);中位生存期分别为13个月和9个月。结论:A组中位生存期的延长和2年生存率的明显提高可能与中药的治疗作用密切相关,但中药与化疗结合尚未能明显改善治疗有效率。

The integration therapy of traditional and western medicine on the patients of advanced non-small cell lung cancer

Purpose:To ascertain the effect of the integration of traditional and western medicine in treatment of advanced non-small cell lung cancer. Methods: From May 1992 to August 1996, 106 patients with advanced non-small cell lung cancer were divided at random into two groups: group A. 52 cases, treated with traditional chinese medicine (TCM) combination with chemotherapy, group B, 54 cases treated with chemotherapy alone. The protocol of chemotherapy used in the two groups was similar. The chinese medicines were given mainly according to the syndrome differentiation. Four types were found in the group A: the Lung and Spleen Qi Deficiency type, the Lung Heat and Phlegm-Dampness type, the Lung-Yin and Stomach-Yin Difi-ciency type and the Qi Stagnation and Blood Stasis type. Results:The total response rate according to the WHO criteria was as follows: that of group A and group B was 46. 2% and 40. 7% respectively (P>0. 05); the 1 year survival rate of them was 69. 2% and 61. 1 (P>0. 05); the 2 year survival rate was 44. 6% and 16. 6% (P<0. 01), and the median survival time was 13 months and 9 months, respectively. Conclusions:These results suggest that the elevation of median survival time and 2 year sur-vival rate of group A might be closely related with the therapeutic effect of TCM. However, TCM combination with chemothera-py did not improve the response rate significantly.