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The role of fibrin glue instillation under skin flaps in the prevention of seroma formation and related morbidities following breast and axillary surgery for breast cancer: A meta‐analysis
Authors:Muhammad S. Sajid MBBS  MSc   MBA  FRCS  Kristian Hutson MBBS  MRCS  Lorain Kalra MBBS  MRCS  Riccardo Bonomi MBBS  FRCS
Affiliation:Department of Breast and Oncoplastic Surgery, Worthing Hospital, Worthing, West Sussex, UK
Abstract:A systematic review of randomised, controlled trials investigating the effectiveness of fibrin glue (FG) in reducing the postoperative seroma and seroma related morbidities following breast and axillary surgery was conducted. FG failed to influence the incidence of postoperative seroma, average volume of seroma, wound infection, complications and length of hospital stay in patients undergoing breast cancer surgery. However, a major multicentre and high quality randomised, controlled trial is required to validate these findings. J. Surg. Oncol. 2012; 106:783–795. © 2012 Wiley Periodicals, Inc.
Keywords:breast cancer  seroma  mastectomy  axillary dissection  fibrin glue
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