应用16层螺旋CT评价辛伐他汀对冠状动脉斑块的影响

目的 评价辛伐他汀对冠状动脉粥样斑块的影响.方法 对43例经16层螺旋CT及回顾性心电门控技术检测出的冠脉粥样斑块患者,给予辛伐他汀20 mg/d口服,12个月后复查斑块情况.结果 43例患者有119支冠状动脉存在132个粥样斑块,治疗后各种斑块大小有不同程度的缩小,其中脂质斑块(27个)缩小幅度26.4%(P＜0.05),纤维斑块(34个)缩小幅度14.1%(P＜0.05),混合斑块(13个)缩小幅度12.7%(P＜0.05),而钙化斑块(58个)缩小幅度不明显(3.7%,P＞0.05).结论 辛伐他汀可逆转或稳定冠脉粥样斑块,从而降低急性冠状动脉事件的发生;16层螺旋CT可定量评价粥样斑块的变化,为临床治疗提供客观依据.

The evaluation of the influence of simvastatin on coronary artery atheromatous plaque by 16 layers spiral CT

Objective To evaluate the influence of simvastatin on coronary artery atheromatous plaque. Methods 43 cases of coronary artery atheromatous plaque examined with 16 layers spiral CT and retrospectively ECG gated technology, received simvastatin tablets (20 mg/d ) for twelve months, and scan the atheromatous plaque again. Results Of the 43 cases in this study, 132 atheromatous plaques occurred in 119 coronary artery branches. The sizes of all plaques have different degrees of descent after the treatment. The rate of descent is 26.4% in 27 lipoid plaques(P<0.05=, 14.1% in 34 fibrous plaques(P<0.05=, 12.7% in 13 mixed plaques(P<0.05=, 3.7% in 58 calcified plaques(P>0.05). Conclusion Simvastatin can reverse and stabilize the coronary artery atheromatous plaque, and reduce the occurrence of acute coronary artery affairs. 16 layers spiral CT can quantitatively evaluate the changes of atheromatous plaque. It provides objective basis for the clinic treatment.