论单核苷酸多态性与中医证的个体差异

单核苷酸(nucleotide)是基因的基本组成单位，单核苷酸多态性(Single Nacl eotide Poly morPhism,SNP)是指任何两个不同个体之间的单核苷酸序列中均有不同的排列次序，导致遗传变异而形成不同个体的差异性和多样性。它是决定人的个体差异的主要因素，是遗传的变异性所引起。个体差异是个体机体功能相对偏差以保持动态稳定的特征，是潜在的病理因素，其发病具有质化特点。证以质为基础，质以证的形式表现出来，证的特征包含着质的特征，证往往随质而转移，证的个体差异与单核苷酸多态性有关，这是中西医结合研究的最佳切入点。建立证与药的单核苷酸组学，可阐明中医药防治疾病原理，实现个体化医学治疗的理想，体现中医治病求本和防治未病的思想。

A Discussion on Individual Difference between Polymorphism of Mononucleotides and Syndromes of Traditional Chinese Medicine

Mononucleotide is the basic component unit of genes and its polymorphism means the difference and diversity of different individuals, which are formed due to the hereditary variation caused by the different orders of the sequence of mononucleotides between two individuals. The polymorphism of mononucleotide constitutes the main factor that determines the individual difference of human beings and is incurred by hereditary variation. The individual difference is characterized by the relative diviation of individual functions so as to keep their dynamic stability. It is a potentialy pathologic factor and the diseases caused by it have the characteristics of physique. Syndromes are based on physique while physique demonstrates itself in the form of syndromes. The characteristics of syndromes contain those of physique and syndromes usually transfer according to physique. The individual difference of syndromes is related to the polymorphism of mononucleotides and this is the best cutting point in the study on the combination of traditional Chinese and Western medicine. The principles of prevention and treatment of diseases by traditional Chinese medicine can be expounded by the establishment of the science of mononucleotide group of syndromes and medicine, thus realizing the ideal of individualized medical treatment and embodying the ideology of searching for the primary cause of diseases in treatment and the prevention and treatment of future diseases.