雌激素对下丘脑神经元结构及雌激素受体表达水平的影响

目的：观察应用雌激素后老年前期雌性大鼠视前内侧区、弓状核雌激素受体的变化及神经元超微结构的改变。方法：采用免疫组织化学及电镜观察。结果：应用雌激素后视前内侧区、弓状核雌激素受体免疫反应（ER－IR）的表达明显下降，神经元核仁边移、核膜皱折，突触丰富、突触内分泌小泡增多。结论：雌激素可调节下丘脑心血管中枢视前内侧区、弓状核雌激素受体的变化影响神经元的结构及功能。

Effects of estrogen on neuron structure and expression of estrogen receptor in hypotha-lamus

Objective To explore the changes of ER IR and the ultra structure in the medial preoptic area, arcuate nuclei of early aged mice treated with estrogen. Methods Immunohistochemistry assay and electron microscopy were used in this study. Results ER IR in the medical preoptic area and arcuate nuclei were greatly reduced after estrogen was given. The cell nuclei of neurons in these areas migrated towards the side, the nuclear membrane became folded, synapse became richer, and the number of synapse vesicle increased. Conclusion Estrogen can affect the neuron structure and function through the change of estrogen receptor expression in the medial preoptic area and arcuate nuclei of the hypothalamus cardiovascular center.