脑星形细胞瘤组织p73和p53蛋白的表达

目的 :探讨脑星形细胞瘤组织p73和p5 3蛋白的表达及其与星形细胞瘤的病理发生的关系。方法 :利用免疫组化方法检测了 6 3例脑星形细胞瘤组织 (I级 8例 ,II级 2 1例 ,III级 2 4例 ,IV级 10例 )及 10例正常脑组织p73、p5 3蛋白表达。结果 :17例脑星形细胞瘤组织呈p73蛋白阳性表达 ,高病理级别的星形细胞瘤组织p73蛋白阳性表达率 (III、IV级 ,38.2 % )明显高于低病理级别的星形细胞瘤组织 (I、II级 ,13.8% ) (χ2 =4.75 ,P <0 .0 5 ) ,10例正常脑组织均呈阴性表达。在 17例p73蛋白阳性表达的脑星形细胞瘤组织中 ,12例呈p5 3蛋白过度表达。结论 :野生型p73蛋白表达异常可能参与脑星形细胞瘤的病理发生 ,p5 3突变可能与p73表达异常有关。

Expression of p73 and p53 protein in brain astrocytoma

To explore the expression of p73 and p53 protein in brainastrocytoma and to investigate the role of p73 inthe genesis of brain astrocytoma. Meffocd: The expression of p73 and p53 protein was detected by immunohistochemistry in 63cases of asttrocytoma (grade I 8,grade 1I 21,grade 1II 24 and grade 1V 10) and 10 normal brain tissue samples. Res ult: A totalof 17 out of the 63 cases of brain astrocytomas appeared p73 positive. The positivity rate in high pathological grade astrocytornas(grade 1Ⅲ and Ⅳ, 38.2 % ) was higher than that in low grade astrocytomas ( grade I and II, 13.8 % ) ( x2 = 4.75, P < 0. 05 ).None of the 10 normal brain tissues was found p73 positive. Out of the 17 p73 - positive astrocytomas, 12 cases overexpressed p53protein. C onclusion: Abnormal expression of wild p73 may involve in the genesis of astrocytoma. Abnormal expression of p73may be due to mutation of 153.