Tritiated digoxin. XX. Tissue distribution in experimental myocardial infarction |
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Authors: | A J Thompson J Hargis M L Murphy J E Doherty |
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Institution: | 1. Brooks Air Force Base, Texas, USA;2. Department of Medicine, Division of Cardiology, University of Arkansas Medical Center, Little Rock, Ark., USA;3. the Veterans Administration Hospital, Little Rock, Ark., USA |
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Abstract: | The role and potential hazards of digitalis glycoside administration in acute myocardial infarction remain controversial. We investigated the concentration of tritiated digoxin in normal, ischemic, and infarcted left ventricular myocardium of the dog after ligation of the anterior interventricular coronary artery. The normal homogeneous distribution of tritiated digoxin in the normal canine left ventricle was altered following acute myocardial infarction. The ischemic and infarcted zones exhibited a marked diminution in digoxin concentration. Oxidative phosphorylation determinations confirmed tissue hypoxia in the infarcted zone. The gradient of digoxin concentration between normal, ischemic, and infarcted zones of myocardium may potentiate the development of an arrhythmia in the electrically unstable infarcted myocardium. |
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Keywords: | Reprint requests to: A J Thompson Major USAF MC USAF/SAM/NGI Brooks Air Force Base Texas 78235 or Dr J E Doherty Director Division of Cardiology VA-UAMC Complex 300 E Roosevelt Rd Little Rock Ark 72206 |
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