早期应用生长抑素预防吻合口瘘疗效分析

目的：探讨食管贲门癌根治术后早期应用生长抑素预防吻合口瘘的临床价值。方法：将128例食管贲门癌患者随机分为试验组（65例）和对照组（63例），对照组术后采用常规抗感染、胃肠减压、胸腔引流、静脉营养；试验组于对照组治疗基础上于术后当天起皮下注射生长抑素八肽（善宁，善得定），比较两组术后恢复情况及吻合口瘘发生率。结果：试验组胃肠减压量、恢复进食时间等各项指标均优于对照组，试验组吻合口瘘发生率为7．7％（5／65），较对照组20．6％（13／63）明显降低，两组比较差异有统计学意义（P〈0．05）。结论：食管贲门癌根治术后早期应用生长抑素能有效预防吻合口瘘发生。

Clinical value of early application of somatostatin to prevent anastomotic fistula after radical resection of Esophageal and cardiac carcinoma

Objective： To research the clinical value of early application of somatostatin to prevent anastomotic fistula after radical resection of Esophageal and cardiac carcinoma. Methods： Divided 128 patients with esophageal and cardiac carcinoma randomly into trial group （65 cases） and control group （63 cases）. The control group take the conventional treatment with conventional anti - infective, gastrointestinal decompression, chest drainage and intravenous nutrition; The treatment of the test group based on the control and subcutaneous injection of somatostatin （Octreotide, Sandostatin）. Compared these two groups with postoperative recovery and the incidence of anastomotic leak. Results： The test group was better than control group with all the indicators such as the amount of decompression, the recovery time of eating. The incidence of anastomotic fistula of the test group was 7.7% （5/65） , Compared with the control group 20. 6% （ 13/63 ）, the test group was significantly lower （ P 〈 0. 05 ）. We could conclud a significant difference statistically from the two groups. Conclusion： Early application of somatostatin to prevent anastomotic fistula after radical resection of Esophageal and cardiac carcinoma were effective in preventing anastomotic leakage.