COX-2、VEGF、Ki67在子宫内膜癌中的表达及意义

目的探讨环氧合酶-2(COX-2)、血管内皮生长因子(VEGF)和增殖细胞核相关抗原(Ki67)在子宫内膜癌发生、发展中的作用。方法采用免疫组织化学Envision法检测50例子宫内膜癌和15例正常子宫内膜组织中COX-2、VEGF、Ki67的表达。结果子宫内膜癌组织中COX-2、VEGF、Ki67的表达明显高于正常子宫内膜组织(P<0.01);COX-2的高表达与临床分期无关(P>0.05),与分化程度和浸润深度有关(P<0.01);VEGF的高表达与临床分期、浸润深度无关(P>0.05),分化程度有关(P<0.05);Ki67的高表达与临床分期(P<0.05)、分化程度、浸润深度有关(P<0.01)。COX-2与VEGF和Ki67的表达间存在正相关(r=0.39,P<0.01;r=0.32,P<0.05)。结论COX-2、VEGF、Ki67与子宫内膜癌的发生和发展相关,COX-2可通过使VEGF高表达,增加细胞增殖活性促进子宫内膜癌的发生、发展。

Expression of COX-2, VEGF and Ki67 in endometrial carcinoma

Objective To explore the significance of COX-2,VEGF and Ki-67 in the pathogenesis and development of endometrial carcinoma.Methods Expression of COX-2,VEGF and Ki67 was examined in 50 cases of endometrial carcinoma and 15 cases of normal endometrial tissues by immunohistochemical method Envision.Results Expression of COX-2,VEGF and Ki67 in endometrial carcinoma was strikingly higher than that in the normal counterpart(P<0.01).High expression of COX-2 was associated with tumor differentiation and depth of invasion(P<0.01) but was not related to clinical stage(P>0.05).High expression of VEGF was associated with tumor differentiation(P<0.05) but was not related to clinical stage and depth of invasion(P>0.05).High expression of Ki67 was associated with clinical stage(P<0.05),tumor differentiation and depth of invasion(P<0.01).Expression of COX-2 was positively correlated with the expression of VEGF and Ki67(r=0.39,P<0.01;r=0.32,P<0.05).Conclusion COX-2,VEGF and Ki67 were involved in the pathogenesis and development of endometrial carcinoma.COX-2 may function by increasing the expression of VEGF to promote the proliferation of cells.