| Effect of the YI QI HUA YU Recipe on Schwann Cell Activity Following Lumbar Nerve Root Compression |
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| 作者姓名： | Zhou Chongjian Shi Qi Wang Yongjun Hou Baoxing |
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| 作者单位： | Long Hua hospital attached to Shanghai University of TCM，Shanghai 200032 |
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| 基金项目： | 上海市自然科学基金 (0 2 ZB14 0 98) |
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| 摘 要： | Successful regeneration following neuronalinjury requires the induction of a regenerative re-sponse in the injured neurons and an environ-ment favorable for growth.The distal of nerve ,once axonal degeneration has occurred,providesthe appropriate cell - cell,cell - matrix andtrophic support necessary for axonal growth1] .in mammals.Schwann cells have a unique role inregulating the growth of axons during regenera-tion and development.During degeneration,theterminal Schwann cells guide axonal g…
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| 关 键 词： | 益气化瘀方 脊神经根损伤 神经肌肉接头 神经再生 末梢施旺细胞 |
| 文章编号： | 1005-0205(2002)06-0001-05 |
| 修稿时间： | 2002年9月16日 |
Effect of the YI QI HUA YU Recipe on Schwann Cell Activity Following Lumbar Nerve Root Compression |
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| Zhou Chongjian,Shi Qi,Wang Yongjun,Hou Baoxing,et al.Effect of the YI QI HUA YU Recipe on Schwann Cell Activity Following Lumbar Nerve Root Compression[J].Chinese Journal of Traditional Medical Traumatology & Orthopeics,2002,10(6):1-9. |
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| Authors: | Zhou Chongjian Shi Qi Wang Yongjun Hou Baoxing |
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| Abstract: | Objective:To study the effect of the YI QI HUA YU recipe on Schwann cells in a neuromuscular junction after compression of the L5 nerve root in rats.Methods:Using immunohistochemistry, confocal laser scanning techniques and the polyclonal antibody S-100 as a Schwann cell marker, motor endplates were visualized with fluorescein-conjugated a-bungarotoxin(a-BTX). The effects of the YI QI HUA YU recipe on Schwann cells in a neuromuscular junction were observed at 10d? 20d? 30d?and 60d after the L5 nerve root was compressed.Results:The aggregates ,sprouts and extension of terminal Schwann cells during degeneration, the amount of overlap of terminal Schwann cells with endplates and the reformation of neuromuscular junctions during regeneration were superior in cells treated with the YI QI HUA YU recipe than in control cells.Conclusion:The YI QI HUA YU recipe can promote the increase of Schwann cells and enhance regeneration. It can also accelerate the reformation of neuromuscular junctions and reduce regeneration time. |
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| Keywords: | Spinal nerve roots/injuriesNeuromuscular junction Nerve regenerationNerve terminal Schwann cellsYI QI HUA YU recipe |
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