Tachycardia as a potential risk indicator for coronary arterial lesions in Kawasaki disease |
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Authors: | Y Suzuki M Iijima H Sasaki T Muto H Tanaka K Kaneko Y Yamashiro |
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Institution: | (1) Department of Public Health, Juntendo University School of Medicine, Tokyo, Japan, JP;(2) Department of Paediatrics, Yamanashi Prefectural Central Hospital, Yamanashi, Japan, JP;(3) Department of Paediatrics, Koshigaya Municipal Hospital, Saitama, Japan, JP;(4) Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan, JP;(5) Department of Paediatrics, Hino Municipal Hospital 6-1-1 Tama-daira, Hino-shi, Tokyo 191-0062, Japan, Tel.: +81-42-581 2677, Fax: +81-42-587-3408, JP |
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Abstract: | Tachycardia is frequently observed in the acute phase of Kawasaki Disease (KD) patients. However, little is known about the
association between the tachycardia in the acute phase of KD and the development of coronary arterial lesions (CAL). We examined
the association between the mean 24 h heart rate in the acute phase of KD observed using 24 h ambulatory ECG monitoring (24 h-ECG)
and the occurrence of CAL in patients. In a study conducted between 1994 and 1997, 26 patients with KD underwent 24 h-ECG
within the febrile period and before the 9th day of illness. We compared the mean 24 h heart rate based on 24 h-ECG between
patients with and those without CAL. Of 26 patients, 7 had CAL. The groups with and without CAL had similar baseline characteristics.
The mean 24 h heart rate in the group with CAL was significantly higher than that in the group without CAL (144 ± 14 vs. 124 ± 22,
P = 0.033). On multiple regression analysis, the mean 24 h heart rate was significantly correlated with the development of
CAL (P = 0.019).
Conclusion Marked tachycardia detected by 24 h-ambulatory ECG monitoring in the acute phase of Kawasaki disease might provide important
information on the development of coronary arterial lesions.
Received: 18 May 1998 / Accepted in revised form: 23 September 1998 |
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Keywords: | Kawasaki disease Tachycardia Electrocardiography Ambulatory monitoring |
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