妊娠4～8周孕妇血清雌二醇水平及其与先兆流产的关系

目的探讨妊娠4～8周孕妇血清雌二醇（E₂）变化及其与先兆流产的关系。方法选择在济南市妇幼保健院就诊妊娠4～8周孕妇259例，将其分为2组：正常妊娠组（171例），先兆流产组（88例），各组按孕周又分为5个亚组。采用化学发光分析法检测孕妇血清E₂水平。 结果正常妊娠组妊娠4～8周孕妇每周血清E₂水平随妊娠周数增加而增加，且呈正相关（r=0.94, P<0.05）。妊娠4～8周先兆流产孕妇血清E₂水平均低于正常妊娠组相应孕周孕妇水平（P<0.01）。论结先兆流产孕妇各孕周血清E₂水平均显著下降，提示E₂可能是维持早期妊娠的重要因素之一。

Serum estradiol and threatened abortion in pregnancy of 4 to 8 weeks

Objective To explore the relationship between serum estradiol and threatened abortion in women with pregnancy of 4 to 8 weeks.Methods 259 pregnant women,who had conceived from 4 to 8 weeks were previously divided into 2 groups: 171 with normal pregnancy and 88 with threatened abortion,and then each group was divided into 5 subgroups based upon gestational age.Chemiluminescence reaction and dissociation enhanced lauthanide fluoroimmuno-assay were used to determine the serum esrtadiol levels.Results With an increase of age,the level of serum E2 in women with normal pregnancy significantly increased(r=0.94,P<0.05),while,the serum E2 level in women with threatened abortion was significantly lower than that in normal pregnancy at the same gestational age.Conclusion The serum level E2 is significantly decreased in women with threatened abortion,suggesting that serum E2 should be an important factor supporting early pregnancy.