| 刺五加总苷片制备工艺及其质量标准研究 |
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| 引用本文： | 曲中原,金哲雄. 刺五加总苷片制备工艺及其质量标准研究[J]. 现代药物与临床, 2008, 0(3) |
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| 作者姓名： | 曲中原 金哲雄 |
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| 作者单位： | 哈尔滨商业大学药学院; |
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| 摘 要： | 目的 对刺五加总苷片制备工艺进行优选并建立片剂的测定方法.方法 采用L9(34)正交试验法考察影响片剂制备工艺的各因素(A:淀粉用量;B:糊精用量;C:蔗糖用量),以多指标综合评分法进行直观分析及方差分析,筛选出符合片剂成型质量要求的处方,并运用高效液相色谱法测定刺五加总苷片中丁香苷的量,对制剂的质量标准进行研究.结果 最佳处方为A2B3C1,即刺五加总苷浸膏粉末20 g、淀粉10 g、糊精15 g、蔗糖2 g;以HPLC法测定该片剂中丁香苷的量,方法精密度、稳定性、重现性良好,回收率为98.8%,RSD为0.69%(n=6).结论 此工艺简单易行,稳定可行,适于工业化生产;拟定的质量标准稳定、可靠.
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| 关 键 词： | 刺五加总苷片 正交试验 质量标准 |
Studies on the preparation technology and quality control standard of total eleutheroside tablet |
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| QU Zhong-yuan JIN Zhe-xiong Pharmaceutical College,Harbin University of Commerce,Harbin,China. Studies on the preparation technology and quality control standard of total eleutheroside tablet[J]. Drugs & Clinic, 2008, 0(3) |
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| Authors: | QU Zhong-yuan JIN Zhe-xiong Pharmaceutical College Harbin University of Commerce Harbin China |
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| Abstract: | Objective To study the best composition of total eleutheroside tablet and to establish an analysis method of measuring the content of it.Methods The L_9(3~4)orthogonal table and the multi- target grading method was applied were employed to select the best formulation by means of starch, dextrin,and sucrose as the three main factors in which all factors been selected of three levels.HPLC method was used to determine the content of syringin in total eleutheroside tablet.Results The tablets were successfully p... |
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| Keywords: | total eleutheroside tablets orthogonal design quality control standard |
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