| 吸入粉雾剂工程颗粒技术研究 |
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| 引用本文： | 李岩峰,周振泽,杨新意,王爱潮,任树龙,杜晓英,何光杰. 吸入粉雾剂工程颗粒技术研究[J]. 现代药物与临床, 2019, 42(12): 2343-2347 |
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| 作者姓名： | 李岩峰 周振泽 杨新意 王爱潮 任树龙 杜晓英 何光杰 |
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| 作者单位： | 天津药业研究院有限公司, 天津 300462,天津药业研究院有限公司, 天津 300462,天津药业研究院有限公司, 天津 300462,天津药业研究院有限公司, 天津 300462,天津药业研究院有限公司, 天津 300462,天津药业研究院有限公司, 天津 300462,天津金耀集团有限公司, 天津 300450 |
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| 基金项目： | 国家科技部重大专项（2017ZX09201002） |
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| 摘 要： | 对于吸入粉雾剂来说，由于活性药物成分（API）较小的粒径和较高的表面能，导致微粉易于团聚，难以分散。微粒间的内聚力和微粒与乳糖间的粘附力导致粉雾剂产品较低的微细粒子比例（FPF）。通过工程颗粒可以改善API微粒的物化性质，进而显著提高DPI产品的递送效率。概述通过工程颗粒的制备API微粉的方法，包括反溶剂结晶、湿法粉碎/研磨、喷雾/冷冻干燥、超临界流体等方法，可以显著提高粉雾剂的雾化性能。
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| 关 键 词： | 吸入粉雾剂 工程颗粒 雾化性能 |
| 收稿时间： | 2019-10-25 |
Study on engineer particle technology of DPIs |
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| LI Yanfeng,ZHOU Zhenze,YANG Xinyi,WANG Aichao,REN Shulong,DU Xiaoying and HE Guangjie. Study on engineer particle technology of DPIs[J]. Drugs & Clinic, 2019, 42(12): 2343-2347 |
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| Authors: | LI Yanfeng ZHOU Zhenze YANG Xinyi WANG Aichao REN Shulong DU Xiaoying HE Guangjie |
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| Affiliation: | Tianjin Pharmaceutial Research Institute Co., Ltd, Tianjin 300462, China,Tianjin Pharmaceutial Research Institute Co., Ltd, Tianjin 300462, China,Tianjin Pharmaceutial Research Institute Co., Ltd, Tianjin 300462, China,Tianjin Pharmaceutial Research Institute Co., Ltd, Tianjin 300462, China,Tianjin Pharmaceutial Research Institute Co., Ltd, Tianjin 300462, China,Tianjin Pharmaceutial Research Institute Co., Ltd, Tianjin 300462, China and Tianjin KingYork Group Co., Ltd, Tianjin 300450, China |
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| Abstract: | Asa result of small particles size and high surface energy,Active Pharmaceutical Ingredients of DPIs tend to be highly agglomerated and poor dispersible. The DPIs exhibit low FPF due to the cohesion between fine particles and adhesion between fine particles and lactose. Through engineering particles, the physical and chemical properties of API particles can be improved, and the delivery efficiency of DPI products can be significantly improved.Methods of engineering particles were reviewed in the paper,involved antisolvent crystallized,wetmillingnanotechnology,spray/spray-freeze drying.The semethods can significantly improveatomization performance off ogging agent. |
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| Keywords: | DPIs engineer particles aerosol properties |
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