环孢素A联合糖皮质激素治疗蚕食性角膜溃疡的疗效

目的:研究环孢素A联合糖皮质激素对蚕食性角膜溃疡的疗效。方法:选取2015-05/2018-05在我院就诊的蚕食性角膜溃疡患者200例,根据治疗方式的不同分为联合组和糖皮质激素组,各100例。糖皮质激素组给予糖皮质激素进行治疗,联合组在糖皮质激素组的基础上给予环孢素A治疗。检测患者C反应蛋白(CRP)、白介素-6(IL-6)水平,评估生存质量,检查临床症状,比较两组治疗有效率、复发率、不良反应发生率。结果:两组治疗后CRP、IL-6水平低于治疗前,生存质量高于治疗前(P<0.05)。联合组治疗后CRP、IL-6水平低于糖皮质激素组治疗后,生存质量高于糖皮质激素组治疗后(P<0.05)。联合组结膜充血消退时间、眼痛消失时间、溃疡愈合时间低于糖皮质激素组(P<0.05)。联合组治疗有效率高于糖皮质激素组,复发率低于糖皮质激素组(P<0.05)。结论:环孢素A联合激素治疗蚕食性角膜溃疡效果显著,能改善患者临床症状,降低炎症反应,提高患者生活质量,降低复发。

Effect of cyclosporine A combined with glucocorticoid in the treatment of corneal ulcer

AIM: To study the effect of cyclosporine A combined with glucocorticoid in the treatment of corneal ulcer.

METHODS: From May 2015 to May 2018, 200 patients with corneal ulcer were selected and divided into combined group and glucocorticoid group according to different treatment methods, 100 cases each. In the combined group, cyclosporine A was given on the basis of the glucocorticoid group. C-reactive protein(CRP)and interleukin-6(IL-6)were measured to evaluate the quality of life, clinical symptoms, treatment efficiency, recurrence rate and incidence of adverse reactions.

RESULTS: After treatment, the levels of CRP and IL-6 in the two groups were lower than that before treatment, and the quality of life was higher than that before treatment(P<0.05). The level of CRP and IL-6 in the combined group was lower than that in the glucocorticoid group, and the quality of life was higher than that in the glucocorticoid group(P<0.05). The time of conjunctival hyperemia, ophthalmalgia and ulcer healing in the combined group were lower than those in the glucocorticoid group(P<0.05). The effective rate of combined group was higher than that of glucocorticoid group, and the recurrence rate of combined group was lower than that of glucocorticoid group(P<0.05).

CONCLUSION: Cyclosporine a combined with hormone is effective in the treatment of corneal ulcer, which can improve the clinical symptoms, reduce the inflammation, improve the quality of life and reduce the recurrence.