Recurrence of familial interstitial nephritis following renal transplantation. |
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| Authors: | Christopher F Wong Kottarathil A Abraham Anthony M Dorman J Joseph Walshe |
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| Institution: | Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland. |
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| Abstract: | |
Introduction
| Hereditary renal disease is not an uncommon cause of end-stagerenal failure (ESRF) and accounts for 15.7% of the patientsin the Irish dialysis population 1]. Adult polycystic kidneydisease was the underlying diagnosis in the majority (68%) ofthese individuals. Although familial interstitial nephritisis rare, we have previously reported two siblings who developedESRF as a consequence 2]. They also had retinitis pigmentosabut did not fit into any previously described renal-retinalsyndrome. Both patients have since undergone successful cadavericrenal transplantation but have subsequently developed recurrenceof their disease with ultimate graft loss. The implicationsof these findings are discussed.
Case 1
| A 16-year-old female was admitted with worsening night blindnessand renal failure in 1988. She was obese and her IQ was estimatedat 130 using the Wechsler Adult Intelligence Scale
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| Keywords: | familial interstitial nephritis recurrence renal transplantation |
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