盐酸溴己新阿莫西林胶囊的一般药理学和毒理学研究

目的 :探讨盐酸溴己新阿莫西林胶囊对动物神经、心血管和呼吸系统的影响及毒性。方法 :小鼠一次性口服 (ig)药物后 ,测定其对神经系统的影响和耐受性 ;腹腔注射 (ip)测其LD50;记录给猫灌药后不同时间的心电图和呼吸变化 ;大鼠按不同剂量ig2个月作长期毒性研究。结果 :本品对小鼠的自主活动无影响 ,与安钠咖和戊巴比妥钠均无协同作用和抑制作用 ;对猫的心血管系统和呼吸均无影响 ;小鼠ig的最大耐受量大于24g/kg;ip的LD50 为3842.82mg/kg;给大鼠ig2个月 ,对动物的各项检查指标均无影响。结论 :本品对动物的神经、心血管和呼吸系统均无影响 ,长期服用本品无明显毒副作用 ,服用安全

THE GENERAL PHARMACOLOGIC AND TOXICOLOGIC STUDIES OF BROMHEXINE HYDROCHLORIDE AND AMOXICILLIN CAPSULE

Objective: To study the effects and toxicities of bromhexine hydrochloride and amoxicillin capsule on nervous, cardiovascular and respiratory systems of the animals. Method: determining the effects and tolerance of the drug on nervous system after giving mice drug orally at one time; determining LD50 after i.p.; recording ECG and respiratory variations of the cats in different time after giving the drug orally; doing long-term toxicological test with different doses for two months. Results: The drug had no any effect on autonomic activities of the mice and no synergistic and inhibitory effects when it used with sodium benzoate and sodium pentobarbital. It had no effect on cardiovascular and respiratory systems of the cats. The maximal tolerance dose to mice orally was more than 24 g/ kg and LD50 of i.p. was 3842.82 mg/ kg. There was no any effect on various testing indications of the rats after two months. Conclusion: The drug has no effects on nervous, cardiovascular and respiratory systems of the animals. Taking the drug for long time may have no prominent side or toxic effects.