利用低频振幅算法在正常人静息态下的脑性别差异磁共振研究

目的:采用静息态功能磁共振成像(resting-state functional MRI,rfMRI)技术,探讨正常人静息态下脑低频振幅(amplitude of low frequency fluctuation,ALFF)的性别差异。方法:对19例男性健康者与19例年龄、受教育程度相匹配的女性健康者进行磁共振静息态扫描,使用ALFF算法对比分析MRI数据,观察男女性血氧水平依赖(blood oxygenation level dependent,BOLD)信号振荡幅度不同的区域。结果:较女性健康组,男性健康组双侧中央前回、双侧额中回、双侧颞上回区域的ALFF值更高;较男性健康组,女性健康组左丘脑、左角回、右海马旁回、后扣带回、脊髓小脑区域的ALFF值更高。结论:静息态下正常人的脑神经活动存在性别差异。

THE STUDY OF AMPLITUDE OF LOW FREQUENCY FLUCTUATION IN HEALTHY MEN AND WOMEN AT RESTING STATE

Objective:To study the amplitude of low frequency fluctuation(ALFF) at the resting state fMRI in healthy men and women,and discussed its underlying neuro-pathophysiological mechanism.Methods:The resting state fMRI data of 19 men and 19 women who performed ALFF were analysis.The amplitude of the blood oxygenation level dependent(BOLD) activation of the resting state brain was investigated.The brain structures having ALFF increase and decrease were demonstrated.Results:The ALFF increased and decreased symmetrically in the brain regions.The increased involvement of men located in bilateral precentral gyrus,bilateral middle frontal gyrus and bilateral superior temporal gyrus.The increased involvement of women covered the limbic system such as parahippocampal gyrus,posterior cingulate gyrus;the spinal cord cerebellum,etc.Conclusion:There are sex differences of nervous activity at resting state.