| CXCR3单核苷酸多态性与肾移植急性排异关系的研究 |
| |
| 引用本文： | 蒋宇光,彭文翰,王慧萍,何强,寿张飞,吴建勇,陈江华.CXCR3单核苷酸多态性与肾移植急性排异关系的研究[J].内蒙古医学院学报,2012,34(4):272-276. |
| |
| 作者姓名： | 蒋宇光 彭文翰 王慧萍 何强 寿张飞 吴建勇 陈江华 |
| |
| 作者单位： | 1. 首都医科大学附属北京朝阳医院泌尿外科,北京,100020
2. 浙江大学医学院附属第一医院肾病中心 |
| |
| 基金项目： | 浙江省卫生厅重点支持项目 |
| |
| 摘 要： | 目的:研究CXCR3基因rs 2280964单核苷酸多态性(gene single nucleotide polymorphisms,SNPs)与肾移植急性排异(acute rejection,AR)发生的关系.方法:2005 - 08～ 2009 - 12行首次同种异体尸体肾移植(re-nal transplantation,RTx)手术、术后6mo内临床及病理均证实的AR或移植肾状态(RTx status,Ts)的受者共223例.总结两组受者术后6mo内AR的发生等流行病及临床资料,用Taqman荧光探针法对CXCR3基因SNPs( In-tron 1,c.12+ 234G＞A；dbSNP:rs2280964)进行基因分型.结果:RTx受者CXCR3基因rs 2280964的SNPs基因分型与术后6mo内AR的发生无明显相关性(男:P=0.36；女:P =0.98).结论:CXCR3基因rs 2280964的SNPs与肾移植受者术后半年内AR的发生无明显相关性.
|
| 关 键 词： | CXCR3 肾移植 急性排异 SNPs |
THE ASSOCIATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISMS IN CXCR3 AND ACUTE REJECTION IN RENAL TRANSPLANTATION |
| |
| Institution: | JIANG Yu-guang,PENG Wen-han,WANG Hui-ping,et al.(Department of Urology,Affiliated Chao-yang Hospital of Capital Medical University,Beijing 101300 China) |
| |
| Abstract: | Objective:To study the association between CXCR3 gene single nucleotide polymorphisms(SNPs)and acute rejection(AR)in renal transplantation(RTX).Methods:A retrospective cohort of 223 patients receiving their first cadaver RTX between aug.2005 and Dec 2009 was studied.Clinical and pathological data were investigated retrospectively.We genotyped the CXCR3 gene SNPs(Intron 1,c.12+234G>A;dbSNP:rs2280964)using TaqMan SNP Genotyping Assays System by Taqman real-time PCR.The associations between CXCR3 gene SNPs and AR episode within the first 6 months after RTX were analyzed.Results:Eighty-eight RTX recipients experienced AR within first 6 months after RTX.The CXCR3 gene SNPs were not significantly related to AR episode within first 6 months after RTX(R C X2test,Male:P=0.36;Female:P=0.98).Conclusion:Our data indicate that CXCR3-rs 2280964 gene SNPs had no association with the occurrence of AR within first 6 months after RTX |
| |
| Keywords: | Kidney rejection CXCR3 SNPs |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
