首页 | 本学科首页   官方微博 | 高级检索  
     


Update on prostate cancer in black men
Authors:Mudashiru A. Salami MBBS  Blessing Etukakpan MBBS  E. Oluwabunmi Olapade-Olaopa MD  FRCS  FWACS
Affiliation:

aDepartment of Surgery, University College Hospital, Ibadan, Nigeria

bDepartment of Surgery (Division of Urology), College of Medicine, University College Hospital, University of Ibadan, Ibadan, Nigeria

Abstract:

Background

Carcinoma of the prostate (CaP) is the most common male malignancy worldwide and the highest incidence has been recorded in black men. CaP appears to have a more aggressive biology in this sub-population but the reasons for these observed differences have not been fully elucidated. This article is a review of the current published evidence on the disease in black men.

Methods

We searched Pubmed and Google for articles on CaP with an emphasis on those focusing on sub-population differences. Published abstracts of presentations at international scientific meetings were also reviewed.

Results

Molecular studies suggest that black men have a genetic predisposition to the development and/or progression of CaP. Variations in several genes and cellular pathways have been implicated in their increased CaP risk. Clinicopathologic differences include more prevalent and extensive high grade prostatic intraepithelial neoplasia (HGPIN) and higher prostate-specific antigen (PSA) values at initial diagnosis. Sociocultural differences in access and uptake of health care resulting in delayed presentation along with differential care are also thought to contribute to the poorer outcomes associated with prostatic malignancy in black men.

Conclusion

Considerable evidence exists on the effect of black ethnicity on the molecular and clinical characteristics of CaP. More studies into the racial differences in the incidence and prognosis of CaP are required to provide information about the mechanisms responsible for this observation.
Keywords:Cancer   Carcinoma of the prostate (CaP)   Ethnicity   Prostate   Epidemiology   Black men
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号