| 环孢素A发酵新工艺 |
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| 引用本文： | 陈代杰,李继安,戈梅,吴晖,吴萍. 环孢素A发酵新工艺[J]. 中国医药工业杂志, 2001, 32(11): 481-484 |
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| 作者姓名： | 陈代杰 李继安 戈梅 吴晖 吴萍 |
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| 作者单位： | 1. 上海医药工业研究院,
2. 杭州中美华东制药有限公司, |
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| 摘 要： | 通过在实验室和生产规模对环孢素A发酵工艺的研究，获得了一条新的发酵工艺，将该新工艺应用于20t生产罐，使环孢素A平均发酵单位比原工艺提高近一倍，有效组分提高约7％，新工艺生产一年多来稳定性良好。
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| 关 键 词： | 环孢素A 发酵 工艺 免疫抑制剂 CyA |
| 文章编号： | 1001-8255(2001)11-0481-04 |
| 修稿时间： | 2000-08-28 |
An Improved Fermentation Technology of Cyclosporin A |
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| CHEN Dai-Jie ,LI Ji-An ,GE Mei ,WU Hui ,WU Ping. An Improved Fermentation Technology of Cyclosporin A[J]. , 2001, 32(11): 481-484 |
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| Authors: | CHEN Dai-Jie LI Ji-An GE Mei WU Hui WU Ping |
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| Affiliation: | CHEN Dai-Jie 1,LI Ji-An 1,GE Mei 1,WU Hui 2,WU Ping 2 |
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| Abstract: | An improved fermentation technology of cyclosporin A was achieved and applied in 20 t fermentor,the productivity of cyclosporin A was nearly doubled and its A c omponent was increased by 7%.The stability of this new technology was good after more than one year's application in production scale. |
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| Keywords: | cyclosporin A fermentation technology |
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