| 不同致敏原诱发过敏性鼻炎模型的比较 |
| |
| 引用本文： | 董培良,殷鑫,张天宇,曲娜,韩华. 不同致敏原诱发过敏性鼻炎模型的比较[J]. 中国药师, 2014, 0(2): 196-198 |
| |
| 作者姓名： | 董培良 殷鑫 张天宇 曲娜 韩华 |
| |
| 作者单位： | 黑龙江中医药大学中医药研究院 哈尔滨 150040；;黑龙江中医药大学药学院;黑龙江中医药大学药学院;黑龙江中医药大学药学院;黑龙江中医药大学药学院 |
| |
| 基金项目： | 黑龙江省自然科学基金项目（编号：D201038） |
| |
| 摘 要： | 目的：不同致敏原诱发豚鼠过敏性鼻炎模型的比较。方法：分别以卵蛋白（OVA）、2，4-二异氰酸甲苯酯（TDI）和互隔交链孢霉作为致敏原诱发豚鼠制备过敏性鼻炎模型，以行为学观察、血清生化水平和组织学观察，考察不同模型组与人类过敏性鼻炎的符合度。结果：OVA组与空白组比较，打喷嚏次数、抓鼻次数、血清透明质酸（HA）及IgE差异有统计学意义（P〈0．001或0．01）。结论：OVA诱发过敏性鼻炎模型既在症状上符合过敏性鼻炎的典型症状，又在病理改变上与过敏性鼻炎相符合。
|
| 关 键 词： | 过敏性鼻炎 模型 致敏原 |
| 收稿时间： | 2013-10-09 |
| 修稿时间： | 2013-11-27 |
Comparison of Allergic Rhinitic Models Induced by Various Allergens |
| |
| Dong Peiliang,Yin Xin,Zhang Tianyu,Qu Na and Han Hua. Comparison of Allergic Rhinitic Models Induced by Various Allergens[J]. China Pharmacist, 2014, 0(2): 196-198 |
| |
| Authors: | Dong Peiliang Yin Xin Zhang Tianyu Qu Na Han Hua |
| |
| Affiliation: | 2 ( 1. Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China ;2. College of Pharmacy, Heilongjiang University of Chinese Medicine) |
| |
| Abstract: | Objective： To compare the models of guinea pig allergic yhinitis induced by different allergens. Methods： Ovalbumin （OVA）, 2,4-tolylene diisocyanate （TDI） and ahernariaalternata was respectively used as the allergens to establish the model of guinea pigs allergic rhinitis. The conformity of the models and human allergic rhinitis was studied through the behavioral indices, such as the times of nose itches, nasal discharge flow, histological properties and serum HA and IgE indices. Results： The times of sneezing and scratching nose, serum HA and lgE in OVA group was significantly different from those in the control group （ P 〈 0.001 or P 〈 0.01 ）. Conclusion： The models of allergic rhinitis induced by OVA are the same as allergic rhinitis in typical symptoms and pathological changes. |
| |
| Keywords: | Allergic rhinitis Models Allergen |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《中国药师》浏览原始摘要信息 |
|
点击此处可从《中国药师》下载全文 |
|
