甲泼尼龙联合常规治疗儿童重型手足口病观察

目的：探讨常规治疗基础上加用糖皮质激素甲泼尼龙治疗重型手足口病（HFMD）的疗效。方法：重型HFMD患儿120例随机分为激素组和非激素组各60例，非激素组给予常规治疗，激素组在此基础上加用甲泼尼龙2mg·kg-1·d-1治疗。5d后比较两组患儿退热时间、止痉时间、住院时间及疱疹消退时间。结果：激素组患儿发热、抽搐、疱疹消退时间明显优于对照组（P〈0.05）。但两组患儿住院天数差异无统计学意义（P〉0.05）。结论：标准治疗基础结合糖皮质激素治疗儿童重型手足口病HFMD有较好的临床疗效。

Curative Effect of Methylprednisolone Combined with Conventional Treatment on Severe Hand foot mouth Disease in Children

Objective： To explore the clinical effect of glucocorticoid methylprednisolone combined with the conventional treatment on severe hand-foot-mouth disease （HFMD） in children. Methods：One hundred and twenty children with severe HFMD from our hospital were randomly divided into the hormone group and non hormone group with 60 cases each. The non-hormone group was treated with western routine therapy, and the hormone group was treated with glucocorticoid methylprednisolone 2mg·kg-1·d-1 additionally. The changes in such symptoms as fever, rash, surprised and chatter, drowsiness and shock were recorded in all cases. The disappearance time of febrile, shock and herpes and hospital stay were compared between the two groups. Results：The clinical effect of the hormone group was better than the non-hormone group; it could shorten the disappearance time of febrile, shock, herpes and pharyngeal buccal redness （P〈0.05）, while showed no effect on the hospital stay. Conclusion：Glucocorticoid combined with the routine therapy in the treatment of severe HFMD in infants exhibits better clinical effect.