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复方降糖玉液联合二甲双胍和格列美脲治疗2型糖尿病
引用本文:林俊杰,卢昉,张间霞. 复方降糖玉液联合二甲双胍和格列美脲治疗2型糖尿病[J]. 中国药师, 2014, 0(2): 268-270
作者姓名:林俊杰  卢昉  张间霞
作者单位:佛山市中医院药剂科; 广东佛山 528000;佛山市中医院内分泌科;;佛山市中医院检验科
摘    要:目的:观察复方降糖玉液联合盐酸二甲双胍和格列美脲治疗2型糖尿病(气阴两虚证)的临床疗效和安全性。方法:80例2型糖尿病(气阴两虚证)患者随机分为观察组和对照组各40例,两组患者均给予盐酸二甲双胍片0.25~0.5g,po,tid和格列美脲片1~2mg,po,qd治疗,观察组在此基础上加服复方降糖玉液10ml,po,tid。治疗12周后观察两组患者空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)及中医证候积分变化,评价临床疗效。结果:治疗后两组FPG、2hPG及HbA1c较治疗前明显下降,且观察组下降明显优于对照组(P<0.05或0.01);观察组中医证候积分下降明显优于对照组(P<0.01);观察组临床显效率为47.5%,高于对照组(P<0.05)。结论:复方降糖玉液能有效降低2型糖尿病(气阴两虚证)患者的血糖,显著改善临床症状,安全性好,值得临床推广应用。

关 键 词:复方降糖玉液  2型糖尿病  气阴两虚证
收稿时间:2013-07-29
修稿时间:2013-10-11

Effect of Compound Hypoglycemic Yuye Oral Liquor Combined with Metformin and Glimepiride on of Type 2 Diabetes Mellitus
Lin Junjie,Lu Fang and Zhang Jianxia. Effect of Compound Hypoglycemic Yuye Oral Liquor Combined with Metformin and Glimepiride on of Type 2 Diabetes Mellitus[J]. China Pharmacist, 2014, 0(2): 268-270
Authors:Lin Junjie  Lu Fang  Zhang Jianxia
Affiliation:1. Department of Pharmacy; 2. Department of Endocrinology; 3. Clinical Laboratory, Foshan Hospital of TCM,Guangdong Foshan 528000, China)
Abstract:Objective: To observe the clinical efficacy and safety of compound hypoglycemic Yuye oral liquor combined with metfoma and glimepiride in the treatment of type 2 diabetes mellitus (deficiency of both Qi and Yin). Methods: Totally 80 type 2 diabetes mellitus patients were randomly divided into the treatment group and the control group with 40 each, both groups were treated with metformin hydrochloride tablets and glimepiride tablets, the treatment group was given compound hypoglycemic Yuye oral liquor additionally, and the treatment duration was 12 weeks. At the end of the treatment, fasting plasma glucose(FPG), postprandial 2 hours plasma glucose(2hPG), hemoglobin A1c(HbA1c)and traditional Chinese medicine (TCM ) syndrome in the two groups were compared. Results:In both groups, FPG, 2hPG and HbAlc were decreased after the treatment, and the decrease in the treatment group was more notable than that in the control group with statistically significant difference (P〈0.05 or P〈0.01). As for TCM syndrome, the score in the treatment group was lower than that in the control group with statistically significant difference (P〈0.01). The clinical efficiency in the treatment group was 47.5%, that was 22.5% in the control group, and the difference between the two groups was statistically significant (P〈0.05). Conclusion:Compound hypoglycemic Yuyeoral liquor can reduce the blood glucose in type 2 diabetes mellitus patients(deficiency of Qi and Yin), and the improvement of clinical symptom is striking with good safety and clinical application value.
Keywords:Compound hypoglycemic Yuye oral liquor  Type 2 diabetes mellitus  Deficiency of Qi and Yin
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