医源性胰岛素对2型糖尿病患者发生冠脉事件的观察

目的 探讨医源性胰岛素不同剂量对中年2型糖尿病患者合并冠脉事件发生是否关联.方法 对53例使用胰岛素治疗的中年2型耱尿病并伴发冠脉事件的患者进行血清胰岛素和C肽测量,结合冠状动脉造影检查,分别以病变冠状动脉记分和病变冠状动脉支数为因变量,血清胰岛素和C肽测量为自变量,进行单元直线相关分析和多元逐步回归分析.结果 糖尿病合并冠脉事件组血清胰岛素水平显著高于对照组,该组患者日均胰岛素用量多数在30 IU以上;冠脉事件组胰岛素及C肽含量与病变冠状动脉记分呈显著正相关,病变冠状动脉支数与血清胰岛素和C肽呈正相关,并有浓度递增关系.逐步回归分析显示血清胰岛素和C肽与冠状动脉病变程度独立相关;冠状动脉病变程度与胰岛素及C肽呈正相关;血清胰岛素和C肽与冠状动脉病变程度独立相关.结论 医源性胰岛素的剂量对2型糖尿病合并冠状动脉事件的病理生理急性改变存在显著的相关关系.

Effects of remedy given-insulin with different dosage on trigger action of coronary events in middle aged type-2 diabetes mellitus

Objective To explore the effects of remedy-given insulin with a different dosage on the onset of coronary events in middle aged type-2 diabetes mellitus.Methods Fifty-three middle-aged type-2 diabetes mellitus cases who were received insulin treatment with coronary heart disease were processed with insulin and peptic C measured and angiography.The coronary lesions and involved vessel score were repectively analysed using linear regression study.And another 32 type-2 diabetes mellitus without insulin regimen...