Role of Apolipoprotein A-I in Steroid-Induced Activation of DNA and Protein Synthesis in Hepatocytes

It is demonstrated that anabolic effect of steroid hormones is produced by steroid-apolipoprotein A-I complexes. These complexes accelerate not only protein, but also DNA synthesis and produce both cell hypertrophy and hyperplasia. For realization of their anabolic effect steroid hormones are modified by - and -reductases in resident macrophages.