| 人类肿瘤中Tie2阳性单核巨噬细胞研究进展 |
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| 引用本文： | 江楚怡,蔡晶,王泽华,陈媛媛. 人类肿瘤中Tie2阳性单核巨噬细胞研究进展[J]. 肿瘤防治研究, 2021, 48(3): 314-318. DOI: 10.3971/j.issn.1000-8578.2021.20.1145 |
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| 作者姓名： | 江楚怡 蔡晶 王泽华 陈媛媛 |
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| 作者单位： | 430022 武汉，华中科技大学同济医学院附属协和医院妇产科 |
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| 基金项目： | 国家自然科学基金面上项目(82072891)。 |
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| 摘 要： | Tie2阳性单核巨噬细胞（TEMs）是一类表达酪氨酸激酶受体Tie2的单核细胞或巨噬细胞，在人类和鼠类中均有发现，可存在于外周血和组织中，参与肿瘤血管生成、淋巴管生成和免疫抑制等肿瘤微环境的形成。现有研究发现TEMs对于多种肿瘤具有潜在的临床诊断及预后指导意义，有望为肿瘤治疗提供新的靶向策略，本文就TEMs在肿瘤中的研究进展作一综述
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| 关 键 词： | Tie2阳性单核巨噬细胞 血管生成 淋巴管生成 免疫抑制 |
| 收稿时间： | 2020-09-27 |
Tie2 Expressing Monocytes/Macrophages in Human Tumors |
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| JIANG Chuyi,CAI Jing,WANG Zehua,CHEN Yuanyuan. Tie2 Expressing Monocytes/Macrophages in Human Tumors[J]. Cancer Research on Prevention and Treatment, 2021, 48(3): 314-318. DOI: 10.3971/j.issn.1000-8578.2021.20.1145 |
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| Authors: | JIANG Chuyi CAI Jing WANG Zehua CHEN Yuanyuan |
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| Affiliation: | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | Tie2 expressing monocytes/macrophages(TEMs)are a subtype of monocytes or macrophages which expressing tyrosine kinase receptor Tie2.They can exist in peripheral blood and tissues of both human and mouse.TEMs can participate in the formation of tumor microenvironment by accelerating tumor angiogenesis,lymphangiogenesis and immunosuppression.At present,TEMs have been found to have potential diagnostic and prognostic guiding significance for a variety of tumors,and they are expected to provide new directions and strategies for tumor therapy.This paper reviews the research progress of TEMs in tumor. |
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| Keywords: | Tie2 expressing monocytes/macrophages(TEMs) Angiogenesis Lymphangiogenesis Immunosuppression |
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