电离辐射对淋巴管的影响研究进展

电离辐射会造成淋巴管内皮细胞死亡,导致淋巴管结构破坏、功能紊乱和数量减少,对放疗产生负面影响,但也会诱导肿瘤细胞和肿瘤浸润性免疫细胞等细胞分泌多种细胞因子,促进肿瘤相关淋巴管生成,增强抗肿瘤免疫,有利于抗肿瘤治疗。研究电离辐射后淋巴管变化可能是探索放疗与免疫治疗协同抗肿瘤作用的一个途径。本综述从电离辐射后淋巴管形态学改变、电离辐射影响淋巴管分子机制和电离辐射后淋巴管变化在临床中的价值3个角度进行了归纳分析,以期为开展电离辐射对淋巴管影响的研究提供思路。

Research progress in the effects of ionizing radiation on lymphatic vessels

Ionizing radiation can induce the death of lymphatic endothelial cells, leading to structural damage, dysfunction, and reduction of lymphatic vessels, which poses a negative impact on radiotherapy. However, it can also induce tumor cells and tumor-infiltrated immune cells to secrete various cytokines and promote tumor-associated lymphangiogenesis, which favors anti-tumor therapy and improve anti-tumor immunity. Studying the changes in lymphatic vessels after ionizing radiation may be a way to explore the synergistic anti-tumor effects of radiotherapy and immunotherapy. This review summarized the morphological changes in lymphatics after ionizing radiation, the molecular mechanisms for the effects of ionizing radiation on lymphatic vessels, and the clinical value of lymphatic changes after ionizing radiation, aiming to provide ideas for the study of the effects of ionizing radiation on lymphatic vessels.