| 摘 要： | Auto-aggressive CXCR6 + CD8 T cells cause liver immune pathology in NASHMichael DudekNonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease related to obesity, and causes liverdisease and cancer1,2. The accumulation of metabolites leads to cell stress and inflammation in the liver3, but mechanisticunderstandings of liver damage in NASH are incomplete. Here, using a preclinical mouse model that displays key features ofhuman NASH (hereafter, NASH mice), we found an indispensable role for T cells in liver immunopathology.
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