2型糖尿病患者肺功能变化及其影响因素

目的检测2型糖尿病患者肺功能变化并探讨其影响因素。方法对51例2型糖尿病患者与35例正常对照组的肺功能进行检测,同时对糖尿病组肺功能变化进行多因素线性相关分析。结果糖尿病组肺活量(VC)、1s用力呼气容积(FEV1)、最大通气量(MVV)、肺总量(TLC)、肺一氧化碳弥散量(DLco)均明显低于对照组(P<0.05)。多因素线性回归分析表明,FEV1与并发症积分呈显著相关(P<0.05),DLco与HbA1c、并发症积分及HOMA-IR呈显著相关(P<0.05)。结论2型糖尿病患者存在肺通气功能障碍,肺脏可能是糖尿病慢性病变的靶器官之一,控制血糖、改善胰岛素抵抗是其防治重点。

Pulmonary function in type 2 diabetesand its related factors

objective To evaluate the change of pulmonary function in type 2 diabetes and to investigate its related factors. Methods Plumonarry function was investigated in 51 patients with type 2 diabetes and 35 healthy control subjects. Related factors of type 2 diabetes were analyzed with liner regression analysis. Results Vital capacity (VC),forced expiratory volume in first second(FEV1),maximal voluntary ventilation (MVV),maximal voluntary ventilation (TLC) and diffusion capacity for carbonmonoxide of lung (Dlco)were significantly decreased(P<0.05). Liner regression analysis showed that FEV1 was negatively correlated with complication integra(P<0.05),while Dlco was negatively correlated with HbA1c and HOMA-IR(P<0.05). Conclusions Type 2 diabetes have abnormalities of pulmonary ventilatory function and diffusive function,it suggests that the lung may also be the target organ of the chronic pathologic changes of diabetes,Glycemic control and ameliorating insulin resistance is important for the prevention and cure.