温阳化瘀颗粒治疗不孕症患者临床疗效观察研究

目的：观察温阳化瘀颗粒对不孕症患者临床疗效。方法：将来我院就诊的不孕症患者200例,随机分为研究组和对照组（各100例）,研究组给予自拟中药制剂温阳化瘀颗粒口服,对照组给予西药戊酸雌二醇口服,结果：治疗前两组子宫内膜厚度,子宫内膜类型没有显著性差异;治疗后研究组子宫黏膜下血流阻力指数（RI）和搏动指数（PI）分别是0.48±0.17、0.87±0.23,对照组子宫黏膜下血流阻力指数（RI）和搏动指数（PI）分别是0.63±0.15、1.13±0.33,研究组RI和PI明显低于对照组,差异有统计学意义（P〈0.05）;研究组HCG优势卵泡发育数目和临床妊娠率分别是3.91±2.55、20%;对照组为2.73±2.47和6%。研究组HCG优势卵泡发育数目和临床妊娠率明显高于对照组,差异有统计学意义（P〈0.05）。结论：温阳化瘀颗粒能促进子宫内膜生长,改善子宫内膜容受性,有助于胚胎着床,提高妊娠率。

Clinical effects on treating infertile patients with Wenyang Huayu granule

Objective：To observe the effects of Wenyanghuayu granule on endometrial receptivity of infertile patients.Methods 200 infertile patients in our unit were randomly divided into two groups.Study group inclding 100 patients were given oral Wenyanghuayu granule,and control group inclding 100 patients were given oral medicine estradiol valerate.Results：There were no difference in endometrial thickness and endometrial type between two groups.Vascular RI（resistance index） were 0.48±0.17 and 0.63±0.15,pulsatility index were 0.87±0.23 and 1.13±0.33 in study group and control group.Compared with control group,RI and PI of study group were significantly lower（P〈0.05）.The number of dominant follicles and pregnacy rates in study group were 3.91±2.55 and 20%,that in control groups were 2.73±2.47 and 3%.The number of dominant follicles and pregnacy rates in study groups were significatly higher than the control group（P〈0.05）.Conclusion：Wenyanghuayu granule can promote endometrial growth and improve endometrial receptivity,which was benificial for embryo implantation and increasing of pregnancy rate.