| Disabled-2基因与肿瘤的相关研究 |
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| 引用本文： | 邵淑丽,蔡昱. Disabled-2基因与肿瘤的相关研究[J]. 中国癌症杂志, 2005, 15(3): 302-305 |
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| 作者姓名： | 邵淑丽 蔡昱 |
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| 作者单位： | 1. 山西省肿瘤医院妇科,山西,太原,030013
2. 山西医科大学第二临床医学院科医教科,山西,太原,030013 |
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| 摘 要： | 信号转导是一个十分精细、复杂的过程,参与细胞的增殖、分化、成熟和凋亡的每一步。在正常情况下人体组织中的Disabled-2蛋白(Dab2)参与细胞的信号转导使机体保持正常功能,而在有些情况下Dab2蛋白的缺失影响正常信号转导途径,从而细胞发生异型性变化、癌变。本文综述Dab2基因及其相关蛋白的结构、功能及与肿瘤发生机制,并对Dab2这个可能的抑癌基因作进一步探讨。
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| 关 键 词： | Dab2基因 信号转导 肿瘤 |
| 文章编号： | 1007-3639(2005)03-0302-04 |
| 修稿时间： | 2004-09-13 |
Research on the correlation of Disabled-2 gene and tumors |
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| SHAO Shu-li,CAI yu. Research on the correlation of Disabled-2 gene and tumors[J]. China Oncology, 2005, 15(3): 302-305 |
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| Authors: | SHAO Shu-li CAI yu |
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| Abstract: | Signal transduction is a very fine and complicated process that indudes participation in the cell propagation, division, maturation and apoptosis.Under normal circumstance disabled-2( Dab2) in human tissues participates in the signal transduction of the cell in order to allow the body to keep normal functions,but under some circumstances the absence of Dab2 influences the normal signal transduction path,leding to atypical cell changes.and the generation of tumors.This paper is a review on the construction and function of Dab2 and its related gene as well as the relation of Dab2 and tumors generation. |
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| Keywords: | Dab2 gene signal transduction tumor |
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