Role of B cells in vaccine-induced immunity against coccidioidomycosis |
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| Authors: | Magee D Mitchell Friedberg Rhonda L Woitaske Melanie D Johnston Stephen Albert Cox Rebecca A |
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| Affiliation: | Center for Biomedical Inventions, University of Texas Southwestern Medical Center, Dallas, 75390-8573, USA. mitch.magee@asu.edu |
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| Abstract: | We investigated secondary immunity against coccidioidomycosis by using gene expression microarrays. Surprisingly, a high percentage of B-cell-related genes were associated with protective immunity. A functional confirmation of the importance of B cells against coccidioidomycosis was achieved by demonstrating that vaccination was not fully protective in B-cell-deficient MuMT mice. |
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