Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon |
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| Authors: | Gupta Swati B Mast Christopher T Wolfe Nathan D Novitsky Vlad Dubey Sheri A Kallas Esper G Schechter Mauro Mbewe Bernard Vardas Eftyhia Pitisuttithum Punee Burke Donald Freed Dan Mogg Robin Coplan Paul M Condra Jon H Long Romnie S Anderson Kiersten Casimiro Danilo R Shiver John W Straus Walter L |
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| Affiliation: | Merck and Co., Inc., Whitehouse Station, NJ, USA. swati_gupta@merck.com |
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| Abstract: | An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples. |
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