辛伐他汀对高脂血症大鼠脂肪细胞凋亡的影响

目的观察辛伐他汀对高脂血症大鼠脂肪细胞凋亡的影响,探讨辛伐他汀降低血脂的分子生物学机制,为临床应用提供理论和实验依据.方法采用自制高脂饲料制备高脂血症大鼠模型,观察大鼠血脂指标以及脂肪细胞凋亡指数的变化.结果高脂血症组大鼠血清TG、Tch及VLDL-ch含量均显著高于正常对照组(P＜0.01),而辛伐他汀组大鼠血清TG、Tch及VLDL-ch水平较高脂血症组均显著下降(P＜0.01),高脂血症组大鼠血清HDL-ch水平均显著低于正常对照组(P＜0.01),辛伐他汀组大鼠血清HDL-ch较高脂血症组显著增高(P＜.01);且接近正常组水平.高脂血症组大鼠脂肪细胞凋亡指数均显著低于正常对照组(P＜0.01),而辛伐他汀组大鼠脂肪细胞凋亡指数较高脂血症组均显著升高(P＜0.01).结论辛伐他汀降低高脂血症大鼠血脂,促进脂肪细胞凋亡,从而达到治疗作用.

Effect of Simvastatin on lipocyte apoptosis in hyperlipoidemia rat

Objective:Through investigating the effect of simvastatin on lipocyte apoptosis in hyperlipoidemia rat,we researched the molecular mechanism of blood lipid reduction function of simvastatin and provided a principle for the practice of simvastatin in clinic.Methods:To prepare the hyperlipoidemia rats by self-prescribed high calorie diet.The change of blood lipid and the index of lipocyte apoptosis were measured.Results:Compared with the control,the level of TG,Tch and VLDL-ch of hyperlipoidemia rat increased obviously(P<0.01),the level of TG,Tch and VLDL-ch of hyperlipoidemia rat with simvastatin decreased obviously(P<0.01),and the level of HDL-ch of hyperlipoidemia rat decreased obviously(P<0.01),the level of HDL-ch of hyperlipoidemia rat with simvastatin increased obviously(P<0.01) and the index of lipocyte apoptosis was measured.Compared with the control,the level of the index of lipocyte apoptosis of hyperlipoidemia rat decreased obviously(P<0.01),while the index of lipocyte apoptosis of hyperlipoidemia rate with simvastatin increased obviously(P<0.01).Conclusion:During the rats are treated by simvastatin,simvastatin may improve lipocyte apoptosis in order to attain bloodlipid-reduction.