可吸收胶原蛋白线与丝线编织非吸收线在口腔种植中的应用

背景：胶原蛋白线由动物的胶原蛋白制备而成，由于其具备可降解、无排异、易于制备、使用方便等优点，现在已开始大量使用于临床。目的：比较胶原蛋白线与丝线编织线对口腔种植手术切口愈合的影响。方法：100例种植手术患者随机等分为可吸收胶原蛋白线组和丝线编织非吸收性缝线组，分别使用2-0带圆针可吸收胶原蛋白缝合线与4-0带圆针丝线编织非吸收性缝线对伤口进行间断无张力缝合。植入后3，5，7 d观察缝线及伤口愈合情况，植入后第7天拆线，植入后14 d复诊。结果与结论：可吸收胶原蛋白线组患者切口甲级愈合率明显多于丝线编织非吸收性缝线组(P < 0.05)。可吸收胶原蛋白线组患者口腔切口中的2-0带圆针可吸收胶原蛋白缝合线在治疗7 d时大多数被吸收，而丝线编织非吸收线组患者口腔切口中4-0带圆针丝线编织非吸收性缝线未见吸收。且使用2-0可吸收胶原蛋白线的患者口内缝线未见污物附着，线体清洁。而使用4-0丝线编织非吸收线缝合的患者口内可见线体周围有软垢附着。提示胶原蛋白线比丝线编织线更适合口腔种植手术切口的无张力缝合，能够获得更好的愈合效果，且时间能够与伤口愈合时间匹配，并能维持更好的口腔卫生。中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程全文链接：

Absorbable collagen suture and non-absorbable silk suture in oral implantation

BACKGROUND:Collagen suture is made of collagen from animals, and has been widely used because it is absorbable, non-rejection and easy to produce, and convenient in use. OBJECTIVE:To evaluate the effects of collagen suture and silk suture in wound healing after oral implant surgery.METHODS:100 patients undergoing oral implantation were randomly assigned into collagen suture group and silk suture group. A 2-0 circular needle with absorbable collagen sutures and a 4-0 circular needle with non-absorbable silk sutures were employed for tension-free suture in the two groups. After 3, 5, 7 days of oral implantation, suture threads and wound healing were observed. The suture was removed at 14 days, and patients were reviewed at 14 days.  RESULTS AND CONCLUSION:The wound healing was better in the collagen suture group than the silk suture group at grade I (P < 0.05). At 7 days postoperatively, the suture thread was mostly absorbed in the collagen group but not in the silk suture group. In addition, material alba was invisible in the collagen suture group but clear in the silk suture group. These results indicate that the collagen suture is more proper for tension-free suture than the silk suture, which is better matched to the healing time and keeps a better oral environment.