鬼箭羽治疗糖尿病肾病药理机制的研究进展

糖尿病肾病作为糖尿病最常见的微血管并发症，是全球终末期肾功能衰竭的最主要原因，严重影响到患者的生活质量。糖尿病肾病发病机制是复杂的，目前主要有糖脂代谢紊乱、氧化应激、炎症反应等。通过古籍、文献查阅，结合吕仁和、赵进喜、黄文政等全国名老中医的用药经验，发现鬼箭羽在治疗消渴病上运用较多。现代药理研究发现鬼箭羽，通过降糖、降脂、调节糖脂代谢紊乱、调节氧化应激、抗炎、抗肾小球硬化等方面起到保护肾脏的作用，延缓糖尿病肾病的进展。

Research progress on pharmacological mechanism of Euonymus alatus in treatment of diabetic nephropathy

Diabetic nephropathy, as the most common microvascular complication of diabetes, is the most important cause of end-stage renal failure worldwide and seriously affects the quality of life of patients.The pathogenesis of diabetic nephropathy is complex, and currently there are mainly disorders of glucolipid metabolism, oxidative stress, and inflammatory response. Through the ancient books and literature review, combined with the experience of medicine of national famous veteran Chinese medicine practitioners such as Lu Renhe, Zhao Jinxi and Huang Wenzheng, it was found that Guijianyu(Ramulus Euonymi) was more used in wasting-thirst. Modern pharmacological studies have found that Guijianyu play a role in protecting the kidney and slowing the progression of diabetic nephropathy through hypoglycemia, hypolipidemia, regulation of disorders of glucolipid metabolism, regulation of oxidative stress, anti-inflammation, and anti-glomerulosclerosis.