CAD/CAM氧化锆全瓷冠修复对牙周组织的影响

背景：全冠修复体远期疗效的维持很大程度上取决于牙周组织的健康状况。 目的：探讨CAD/CAM氧化锆全瓷冠修复体对牙周组织健康状况的影响。 方法：随机选择需行全冠修复的55例患者64颗基牙作为研究对象，实验组为CAD/CAM氧化锆全瓷冠修复的29例患者32颗基牙，对照组为进行镍铬合金烤瓷冠修复的26例患者32颗基牙。检测两组修复前和修复后12个月的龈沟液含量、肿瘤坏死因子α和白细胞介素6水平，以及牙龈出血指数、牙周探诊深度、菌斑指数及附着丧失。 结果与结论：实验组修复前后各指标比较差异均无显著性意义(P > 0.05)。对照组修复12个月后的龈沟液含量、肿瘤坏死因子α、白细胞介素6、牙龈出血指数、牙周探诊深度及菌斑指数均高于修复前(P > 0.05)。修复12个月后，实验组龈沟液含量、肿瘤坏死因子α、白细胞介素6、牙龈出血指数、牙周探诊深度及菌斑指数均低于对照组(P < 0.05)。表明CAD/CAM氧化锆全瓷冠修复后对牙周组织健康基本无不良影响。中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程全文链接：

Effect of the CAD/CAM zirconia all-ceramic crown restoration on periodontal tissue

BACKGROUND:To maintain the long-term effect of full crown largely depends on the health of periodontal tissues. OBJECTIVE:To explore the effect of CAD/CAM zirconia all-ceramic crown restoration on the state of periodontal health. METHODS:Sixty-four abutments of 55 patients were randomly divided into two groups: the experimental group included 32 abutments of 29 patients which would be restored by CAD/CAM zirconia all-ceramic crowns; the controlled group included 32 abutments of 26 patients which would be restored by Ni-Cr alloy porcelain-fused-to- metal restorations. The volume of gingival crevicular fluid and the levels of interleukin-6 and tumor necrosis factor-α in the two groups were examined at the pre-restoration and post-restoration stages. Meanwhile, periodontal clinical indicators, including sulcus bleeding index, probing depth, plaque index and attachment loss were recorded. RESULTS AND CONCLUSION:No difference in various indexes was found in the experimental group before and after restoration (P > 0.05). At 12 months after restoration, in the control group, the volume of gingival crevicular fluid, the levels of interleukin-6 and tumor necrosis factor-α, sulcus bleeding index, probing depth, and plaque index were all increased (P > 0.05); meanwhile, these indexes in the experimental group were significantly lower than those in the control group (P < 0.05). Experimental findings suggest that the CAD/CAM zirconia all-ceramic crown restoration is more favorable to the health of periodontal tissues.