高铁血红蛋白生成剂(MFA)对急性硫化氢中毒动物治疗作用的实验研究

目的 通过动物实验探讨MAF对急性硫化氢中毒的治疗作用。方法 将40只大鼠分为正常对照组、染毒对照组、美蓝求治组、4－DMAP救治组。以致死浓度的硫化氢染毒2min，对两组救治组动物分别给以美蓝和4－DMAP进行急救，2h后做相应生化及病理检查。结果 两救治组MHb、SMHb显著高于两对照组，4－DMAP组MHb、SMHb明显高于美蓝组；染毒对照组肺组织明显充血、水肿，两救治组主要表现为充血。结论 MFA对急性硫化氢中毒动物起到解毒作用，而4－DMAP效果优于美蓝。

The experimental study onthe treatment of acute hydrogen sulfide intoxication with methemoglobin froming agent(MFA)

Objective To study the therapeutic effect of MFA against acute H2S intoxication. Methods Forty rats were divided into four groups: normal control group, poisoned control group, methylene blue group and 4-DMAP group. The later three groups were exposed to lethal concentration of H2S for 2 minutes, and then the later two rat groups were given methylene blue and 4-DMAP respectively. After 2 hours observation all the animals were killed, and the levels of CK, LDH, AST, ALT, Tb, MHb and SMHb in blood and pathological changes of lung were examined. Results The levels of MHb and SMHb in the two MFA treated groups increased significantly, and those in 4-DMAP group were even higher than those in methylene blue group. The lung tissues in poisoned control group were mainly hyperemia and partly edema, whereas the lungs of the two treated groups mainly appeared hyperemia. Conclusion MFA was proved to be antidotal to H2S poisoning, however, the efficacy of 4-DMAP seemed to be better than that of methylene blue.