血液灌流联合血液透析治疗尿毒症皮肤瘙痒临床观察

目的：探讨血液灌流联合血液透析治疗尿毒症的临床疗效。方法：维持性血液透析患者24例,随机分为两组,治疗组12例,采用血液灌流联合透析治疗;对照组12例,单纯透析治疗。两组均采用肝素抗凝,血流量200～250ml/min,透析液流量500ml/min。检测治疗前后血肌酐、尿素氮、甲状旁腺激素、β2微球蛋白、血压及临床症状。结果：治疗组皮肤瘙痒减轻及甲状旁腺激素、β2微球蛋白清除显著高于对照组（P〈0.05）。结论：血液灌流联合血液透析治疗尿毒症病人,可清除中分子物质,可有效减轻皮肤瘙痒。

Clinical study of treating skin pruritus caused by uremia by hemoperfusion combined with hemodialysis

Objective：To study the effect of hemoperfusion（HP） combined with hemodialysis（HD） on the patients with uremia. Methods：24 maintenance hemodialysis patients were randomly divided into the test group （n=12） and control group （n=12）. The hemoperfusion connected with hemodialysis in series was used in the test group and the hemodialysis in the control group. Anticoagulant is heparin. The hemodialysis blood flow rate was 200-250 ml/min, dialysate flow rate was 500ml/ min. The time of pruritus relief and the level of SCr,BUN ,PTH,β2-MG in the blood were measured before and after treatment. Results：The relief of skin itching and the clearance of PTH and β2-MG were significantly higher in the test group than the control group （P〈0.05）.Conclusion： The treatment of hemoperfusion connected with hemodialysis in series can effectively relieve skin pruritus and clean the middle-large molecular substance.