醇质体在经皮给药方面的应用

对一种新型经皮给药载体——醇质体进行综述研究分析.根据近10年国内外文献,总结醇质体的制备方法、性质、促透机制及应用进展.醇质体性质稳定,制备简单,包封率高,适用于各种性质的药物,与普通脂质体相比,显著提高了透皮速率,能传递药物至皮肤深层,增加药物在皮肤深层的滞留量.醇质体的制备工艺简单,可以包载各种类型的药物(包括水溶性、脂溶性、两亲性以及蛋白多肽类),并能达到较高的包封率.与普通脂质体相比,醇质体可以携带药物到达皮肤深层,并提高其经皮吸收速率；与传递体相比,醇质体更稳定；醇质体还可制成凝胶、贴剂、乳膏等方便临床用药的制剂,因而在局部用药和药物经皮吸收方面具有很好的应用前景.

Application of Ethosomes as Carriers in Dermal and Transdermal Drug Delivery

To introduce ethosomes as novel carriers for dermal and transdermal drug delivery. Based on literatures in the last decade, the preparation methods, characteristics, mechanism of facilitating permeation and application of ethosomes were summarized. It showed that the system of ethosomes was stable, simply prepared and had a high entrapment capacity for molecules of various lyophilicities. The ethosomal system was much more efficient at delivering drugs to the skin in terms of quantity and depth, and could also dramatically enhance the skin permeation of molecules compared with liposomes.Ethosomes is a good carrier for transdermal delivery, and has broad application prospect.